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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tarizzo V, Rubio M C

Gen Pharmacol. 1982;13(2):111-6. doi: 10.1016/0306-3623(82)90065-9.

The present paper is concerned with some pharmacological actions of ionophore A-23187 on both isolated guinea-pig atria and cat's nictitating membrane. 2. The drug showed an agonist effect on both tissues. 3. There is an indirect effect by releasing catecholamines which is antagonized by reserpine and beta receptor blockers in atria and alfa receptor blockers in nictitating membrane. 4. The ionophore exhibited a direct positive chronotropic effect on the atria. This effect is blocked by Ca2+ flux antagonist such as verapamil and pentobarbital and not by reserpine. 5. Ionophore produced no direct effect on the activity of the isolated tyrosine hydroxylase but showed an inhibitory action in intact tissues, mediated by released of endogenous catecholamines, since this effect is antagonized by reserpine. 6. Monoamine oxidase activity was unaffected by ionophore.

本文关注离子载体A - 23187对离体豚鼠心房和猫瞬膜的一些药理作用。2. 该药物对两种组织均表现出激动剂作用。3. 存在通过释放儿茶酚胺产生的间接作用，在心房中这种作用被利血平和β受体阻滞剂拮抗，在瞬膜中被α受体阻滞剂拮抗。4. 离子载体对心房表现出直接的正性变时作用。这种作用被维拉帕米和戊巴比妥等Ca2 + 通量拮抗剂阻断，而不被利血平阻断。5. 离子载体对离体酪氨酸羟化酶的活性无直接作用，但在完整组织中表现出抑制作用，由内源性儿茶酚胺的释放介导，因为这种作用被利血平拮抗。6. 单胺氧化酶活性不受离子载体影响。

Tarizzo V, Rubio M C

Gen Pharmacol. 1982;13(2):111-6. doi: 10.1016/0306-3623(82)90065-9.

The present paper is concerned with some pharmacological actions of ionophore A-23187 on both isolated guinea-pig atria and cat's nictitating membrane. 2. The drug showed an agonist effect on both tissues. 3. There is an indirect effect by releasing catecholamines which is antagonized by reserpine and beta receptor blockers in atria and alfa receptor blockers in nictitating membrane. 4. The ionophore exhibited a direct positive chronotropic effect on the atria. This effect is blocked by Ca2+ flux antagonist such as verapamil and pentobarbital and not by reserpine. 5. Ionophore produced no direct effect on the activity of the isolated tyrosine hydroxylase but showed an inhibitory action in intact tissues, mediated by released of endogenous catecholamines, since this effect is antagonized by reserpine. 6. Monoamine oxidase activity was unaffected by ionophore.

本文关注离子载体A - 23187对离体豚鼠心房和猫瞬膜的一些药理作用。2. 该药物对两种组织均表现出激动剂作用。3. 存在通过释放儿茶酚胺产生的间接作用，在心房中这种作用被利血平和β受体阻滞剂拮抗，在瞬膜中被α受体阻滞剂拮抗。4. 离子载体对心房表现出直接的正性变时作用。这种作用被维拉帕米和戊巴比妥等Ca2 + 通量拮抗剂阻断，而不被利血平阻断。5. 离子载体对离体酪氨酸羟化酶的活性无直接作用，但在完整组织中表现出抑制作用，由内源性儿茶酚胺的释放介导，因为这种作用被利血平拮抗。6. 单胺氧化酶活性不受离子载体影响。