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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kennedy R H, Donnelly T E

Gen Pharmacol. 1982;13(3):231-9. doi: 10.1016/0306-3623(82)90094-5.

This study examined possible effects of chronic beta-adrenergic blockade on (a) rat myocardial beta-adrenergic receptors and (b) the responsiveness of isolated atria and right ventricular strips to various agents. 2. Following withdrawal of propranolol or saline treatment, significant left shifts were noted in the inotropic responses of propranolol-treated right ventricular strips to isoproterenol and norepinephrine. 3. This supersensitivity could not be demonstrated in left atrial inotropic or right atrial chronotropic responses. 4. Treatment and withdrawal did not alter (a) the inotropic responsiveness of right ventricular strips to extracellular calcium, methoxamine, ouabain, glucagon, 3-isobutyl-l-methylxanthine, acetylcholine or methacholine, or (b) beta-adrenergic receptors in ventricular membranes.

本研究考察了慢性β-肾上腺素能阻滞对以下方面的可能影响：(a)大鼠心肌β-肾上腺素能受体，以及(b)离体心房和右心室条带对各种药物的反应性。2. 在停用普萘洛尔或生理盐水处理后，发现普萘洛尔处理的右心室条带对异丙肾上腺素和去甲肾上腺素的变力反应出现显著左移。3. 这种超敏反应在左心房变力反应或右心房变时反应中未得到证实。4. 处理和撤药并未改变：(a)右心室条带对细胞外钙、甲氧明、哇巴因、胰高血糖素、3-异丁基-1-甲基黄嘌呤、乙酰胆碱或氨甲酰甲胆碱的变力反应性，或(b)心室膜中的β-肾上腺素能受体。

Kennedy R H, Donnelly T E

Gen Pharmacol. 1982;13(3):231-9. doi: 10.1016/0306-3623(82)90094-5.

This study examined possible effects of chronic beta-adrenergic blockade on (a) rat myocardial beta-adrenergic receptors and (b) the responsiveness of isolated atria and right ventricular strips to various agents. 2. Following withdrawal of propranolol or saline treatment, significant left shifts were noted in the inotropic responses of propranolol-treated right ventricular strips to isoproterenol and norepinephrine. 3. This supersensitivity could not be demonstrated in left atrial inotropic or right atrial chronotropic responses. 4. Treatment and withdrawal did not alter (a) the inotropic responsiveness of right ventricular strips to extracellular calcium, methoxamine, ouabain, glucagon, 3-isobutyl-l-methylxanthine, acetylcholine or methacholine, or (b) beta-adrenergic receptors in ventricular membranes.

本研究考察了慢性β-肾上腺素能阻滞对以下方面的可能影响：(a)大鼠心肌β-肾上腺素能受体，以及(b)离体心房和右心室条带对各种药物的反应性。2. 在停用普萘洛尔或生理盐水处理后，发现普萘洛尔处理的右心室条带对异丙肾上腺素和去甲肾上腺素的变力反应出现显著左移。3. 这种超敏反应在左心房变力反应或右心房变时反应中未得到证实。4. 处理和撤药并未改变：(a)右心室条带对细胞外钙、甲氧明、哇巴因、胰高血糖素、3-异丁基-1-甲基黄嘌呤、乙酰胆碱或氨甲酰甲胆碱的变力反应性，或(b)心室膜中的β-肾上腺素能受体。