豚鼠的主要组织相容性复合体。II. 混合淋巴细胞反应与豚鼠白细胞抗原B位点和I区血清学定义表型之间的关系。
The major histocompatibility complex of the guinea-pig. II. Relationship between mixed leucocyte reactivity and serologically-defined phenotypes of the GPLA B locus and I region.
作者信息
Geczy A F, de Weck A L
出版信息
J Immunogenet. 1976 Jun;3(3):191-8.
The relationship between the mixed leucocyte reaction (MLR) and the serologically-defined antigens controlled by genes in the guinea-pig B locus (equivalent to the murine D or K region) and I region was investigated in various inbred and partially inbred strains and in guinea-pig families homozygous for their GPLA alleles. No MLR reactions could be detected among guinea-pig families of a closed colony which had been bred to homozygosity for their GPLA antigens. By contrast, animals which differed in their I region showed strong MLR reactivity. Animals with identical I regions as judged by four serologically-defined specificities only, but differ with respect to B locus determinants, yield appreciably lower MLR responses. It appears that in the guinea-pig, as in other mammalian species, the antigenic systems responsible for MLR reactivity are controlled primarily by genes identical with or closely linked to the I region of the major histocompatibility complex.
在各种近交和部分近交品系以及其GPLA等位基因纯合的豚鼠家族中，研究了混合淋巴细胞反应（MLR）与豚鼠B位点（相当于小鼠的D或K区域）和I区域中由基因控制的血清学定义抗原之间的关系。在一个封闭群体中已培育至其GPLA抗原纯合的豚鼠家族中，未检测到MLR反应。相比之下，I区域不同的动物表现出强烈的MLR反应性。仅根据四种血清学定义的特异性判断I区域相同，但B位点决定簇不同的动物，其MLR反应明显较低。看来在豚鼠中，与其他哺乳动物物种一样，负责MLR反应性的抗原系统主要由与主要组织相容性复合体I区域相同或紧密连锁的基因控制。
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