Suzuki K, Nomaguchi T A, Kimura I
Dev Comp Immunol. 1977 Oct;1(4):333-40. doi: 10.1016/s0145-305x(77)80016-5.
Frog larvae recieved transplants of autografts, allografts, and xeonografts using Rana brevipoda and Rana japonica. Tail tip autografts heal rapidly, continue to grow but undergo degeneration at metamorphosis. Allografts and xenografts also heal but show signs of rejection by the host's immune system. Onset of rejection depends upon the stage when grafts were performed. If transplants were made during early stages, onset was late; if performed later, onset was early. Because frog larvae will eventually undergo metamorphosis as a result of thyroxine effects, they are excellent experimental models for correlating the immune and endocrine systems with differentiation, growth, and aging.
使用日本林蛙和日本短脚林蛙对蛙类幼体进行自体移植、同种异体移植和异种移植。尾尖自体移植愈合迅速，能继续生长，但在变态时会发生退化。同种异体移植和异种移植也能愈合，但显示出被宿主免疫系统排斥的迹象。排斥反应的开始取决于进行移植的阶段。如果在早期进行移植，排斥反应开始较晚；如果在后期进行移植，排斥反应开始较早。由于蛙类幼体最终会因甲状腺素的作用而发生变态，它们是将免疫系统和内分泌系统与分化、生长和衰老联系起来的优秀实验模型。
