Behavioral pharmacologic studies in the monkey with DD-3480.

A comparative study has been made of the catalepsy-inducing and antiapomorphine effects of DD-3480, a new butyrophenone derivative, and haloperidol in monkeys. DD-3480 exhibited catalepsy-inducing effects in a dose-dependent manner at oral doses of 2.5-10 mg/kg. This effect was comparable to that of haloperidol, but its duration was shorter in DD-3480 than in haloperidol. An evident anti-apomorphine effect was observed at 2.5 mg/kg of DD-3480 (p.o.); it was slightly stronger than that of haloperidol.