Martin R M, Halsey J H, Reneau D D
Neurol Res. 1982;4(1-2):21-34. doi: 10.1080/01616412.1982.11739614.
The rate of oxygen disappearance from the gerbil cerebral cortex was measured during bilateral carotid artery occlusion with an oxygen microelectrode at normal tissue PO2 and under hyperbaric oxygenation. The oxygen disappearance rate (ODR) was found to be heavily dependent on the PO2 at occlusion due to the desaturation of hemoglobin-bound oxygen. When the tissue PO2 was elevated to a level high enough to saturate hemoglobin, the ODR reflected the oxygen consumption rate which was calculated to range from 1.6-7.4 cc O2/100 cc tissue-min. for ten barbiturate-anesthetized animals. The fall in PO2 was found not to be totally linear to zero in many cases, but instead consisted of a linear phase followed by a period of decreasing slope. We believe this phase of changing slope represents a diminishing oxygen consumption rate. The exact nature of this decrease is not known but perhaps is an inhibitory response to the accumulation of metabolites as a result of the circulation arrest.
在用氧微电极测量正常组织氧分压（PO2）及高压氧合情况下，双侧颈动脉闭塞期间沙土鼠大脑皮质的氧消失率。由于血红蛋白结合氧的去饱和作用，发现氧消失率（ODR）在闭塞时严重依赖于PO2。当组织PO2升高到足以使血红蛋白饱和的水平时，ODR反映了氧消耗率，经计算，10只巴比妥麻醉动物的氧消耗率为1.6 - 7.4立方厘米O2/100立方厘米组织 - 分钟。发现在许多情况下，PO2下降并非完全线性降至零，而是由一个线性阶段接着一个斜率递减阶段组成。我们认为这个斜率变化阶段代表氧消耗率的降低。这种降低的确切性质尚不清楚，但可能是对循环停止导致的代谢产物积累的一种抑制反应。
