Kleinman J E, Weinberger D R, Rogol A, Shiling D J, Mendelson W B, Davis G C, Bunney W E, Wyatt R J
Psychiatry Res. 1982 Aug;7(1):1-7. doi: 10.1016/0165-1781(82)90047-6.
Naloxone produced improvement in abnormal thought content in medicated chronic schizophrenic patients, but not in drug-free patients. In contrast, drowsiness and increases in plasma prolactin concentrations were seen only in drug-free schizophrenic patients. Although growth hormone concentrations increased in drug-free and medicated schizophrenic patients, the time course was different in the two groups. Neuroleptics appear to alter naloxone's clinical and neuroendocrine effects in chronic schizophrenic patients.
纳洛酮可改善接受药物治疗的慢性精神分裂症患者的异常思维内容，但对未服药的患者无效。相比之下，嗜睡和血浆催乳素浓度升高仅见于未服药的精神分裂症患者。虽然未服药和接受药物治疗的精神分裂症患者的生长激素浓度均升高，但两组的时间进程不同。抗精神病药物似乎会改变纳洛酮对慢性精神分裂症患者的临床和神经内分泌作用。
