消化性溃疡疾病患者空腹时胃泌素、生长抑素和胰多肽的血药浓度

Fasting blood levels of gastrin, somatostatin, and pancreatic polypeptide in peptic ulcer disease.

作者信息

Gustavsson S, Adami H O, Björklund O, Enander L K, Lundqvist G, Lööf L, Nordahl A

出版信息

Scand J Gastroenterol. 1982 Jan;17(1):81-5. doi: 10.3109/00365528209181048.

DOI:10.3109/00365528209181048

Abstract

Fasting plasma levels of immunoreactive gastrin, somatostatin, and pancreatic polypeptide (PP) were determined in 67 patients with an endoscopically proven duodenal, pyloric, or prepyloric ulcer. Pretreatment gastrin (45.6 +/- 53.6 pmol/l, mean +/- S.D.) and somatostatin (54.5 +/- 27.5 pg/ml) did not differ significantly from those in 22 healthy controls (21.8 +/- 20.2 pmol/l and 64.8 +/- 24.7 pg/ml, respectively). The gastrin and somatostatin levels were not changed by 3 weeks of treatment either with propantheline and antacids or with cimetidine and antacids. The mean PP value before treatment was significantly (p less than 0.01) higher in duodenal ulcer patients (0.76 +/- 0.55 ng/ml) than in healthy subjects of similar age (0.36 +/- 0.26 ng/ml). The increased PP level was not lowered significantly by medical treatment even when this resulted in healing of the ulcer.

摘要

对67例经内镜证实患有十二指肠、幽门或幽门前溃疡的患者测定了空腹血浆中免疫反应性胃泌素、生长抑素和胰多肽（PP）的水平。治疗前胃泌素（45.6±53.6 pmol/l，均值±标准差）和生长抑素（54.5±27.5 pg/ml）与22例健康对照者（分别为21.8±20.2 pmol/l和64.8±24.7 pg/ml）相比无显著差异。用丙胺太林和抗酸剂或西咪替丁和抗酸剂治疗3周后，胃泌素和生长抑素水平均未改变。十二指肠溃疡患者治疗前的平均PP值（0.76±0.55 ng/ml）显著高于（p<0.01）年龄相仿的健康受试者（0.36±0.26 ng/ml）。即使药物治疗使溃疡愈合，升高的PP水平也未显著降低。