孤立中枢神经系统制剂的发展。

The development of isolated central nervous system preparations.

Kerkut G A

Comp Biochem Physiol C Comp Pharmacol. 1982;72(2):161-9. doi: 10.1016/0306-4492(82)90080-6.

Abstract

Use of invertebrate isolated CNS preparations showed that identified neurons have distinct specific repeatable pharmacological properties. 2. Isolated CNS preparations have been developed from invertebrates to include fish, amphibian, reptile and mammal CNS preparations. 3. The isolated mammalian (mouse, hamster, rat, guinea pig) CNS preparation can remain alive for up to 72 hr and show cells with good resting potentials, action potentials; good functional pathways and tracts; and good responses to drug application. 4. Some possible future developments of isolated mammalian CNS preparations are described.

摘要

对无脊椎动物分离中枢神经系统制剂的使用表明，已识别的神经元具有独特的、特定的、可重复的药理特性。2. 已从无脊椎动物开发出分离中枢神经系统制剂，包括鱼类、两栖类、爬行类和哺乳类中枢神经系统制剂。3. 分离的哺乳类（小鼠、仓鼠、大鼠、豚鼠）中枢神经系统制剂可存活长达72小时，并显示出具有良好静息电位、动作电位的细胞；良好的功能通路和神经束；以及对药物应用的良好反应。4. 描述了分离的哺乳类中枢神经系统制剂未来一些可能的发展情况。