Planz G, Haass H, Lamberts B
Int J Clin Pharmacol Ther Toxicol. 1982 Oct;20(10):469-73.
In seven male hypertensive patients with chronic renal failure (serum creatinine level 6.9 +/- 4.1 mg%) plasma catecholamine levels were in the same range as in five normotensive healthy volunteers. Treatment with the beta-receptor blocker metipranolol (2 x 20 mg/day orally for 2 weeks) significantly elevated plasma catecholamine levels in the hypertensive patients with chronic renal failure, but not in the healthy volunteers. Blood pressure and heart rate were reduced in both groups.
在7名患有慢性肾衰竭的男性高血压患者（血清肌酐水平为6.9±4.1mg%）中，血浆儿茶酚胺水平与5名血压正常的健康志愿者处于同一范围。用β受体阻滞剂美替洛尔（每天口服2次，每次20mg，共2周）治疗后，患有慢性肾衰竭的高血压患者血浆儿茶酚胺水平显著升高，但健康志愿者未出现这种情况。两组的血压和心率均有所降低。
