Schwid H A, Geisler C D
J Acoust Soc Am. 1982 Nov;72(5):1435-40. doi: 10.1121/1.388676.
A probabilistic model is described for transmitter release from hair cells, auditory neuron EPSP's, and discharge patterns. The present model assumes that several reservoirs of neurotransmitter exist, having individual probability-of-release functions centered at successively higher intensities. The model accurately mimics the adaptation of successive EPSP amplitudes of the afferent neuron of the goldfish sacculus and, for mammalian auditory-nerve fibers, the adaptation of neural discharge rate, the saturation of onset and steady-state neural rate versus intensity, and the change in neural rate in response to incremental stimuli. The model also produces realistic interval and period histograms. The data shown support the hypothesis that multiple populations of neurotransmitter are involved in the afferent hair-cell synapses.
描述了一种用于毛细胞递质释放、听觉神经元兴奋性突触后电位（EPSP）和放电模式的概率模型。当前模型假设存在多个神经递质储存库，其各自的释放概率函数以连续更高的强度为中心。该模型准确地模拟了金鱼球囊传入神经元连续EPSP振幅的适应性，对于哺乳动物听觉神经纤维，模拟了神经放电率的适应性、起始和稳态神经率与强度的饱和以及神经率对增量刺激的变化。该模型还产生了逼真的间隔和周期直方图。所示数据支持了传入毛细胞突触涉及多种神经递质群体的假设。
