Florence A T, Whitehill D
J Pharm Pharmacol. 1982 Nov;34(11):687-91. doi: 10.1111/j.2042-7158.1982.tb06201.x.
In order to improve the stability of w/o/w multiple emulsions which have isopropyl myristate as the non-aqueous 'oil' phase, either the internal aqueous phase of the multiple system or the secondary (outer or continuous) aqueous phase can be gelled. Production, by gamma-irradiation, or cross-linked polyacrylamide or poloxamer gels in the aqueous phases of the emulsions leads to systems which have a greater intrinsic stability than untreated multiple emulsions. If the internal aqueous phase is gelled this prevents coalescence. When the continuous outer phase is gelled an opaque emulsion is produced in which the disperse w/o droplets are held in a hydrophilic polymer network from which the droplets are released on contact with water.
为了提高以肉豆蔻酸异丙酯作为非水“油”相的水包油包水多重乳液的稳定性，可以使多重体系的内水相或第二（外相或连续）水相凝胶化。通过γ射线辐照在乳液水相中制备交联聚丙烯酰胺或泊洛沙姆凝胶，得到的体系比未处理的多重乳液具有更高的固有稳定性。如果内水相凝胶化，可防止聚结。当连续外相凝胶化时，会产生不透明乳液，其中分散的油包水液滴被保持在亲水性聚合物网络中，液滴与水接触时会从中释放出来。
