Radha Krishna Murthy K
Jpn Heart J. 1982 Sep;23(5):835-42. doi: 10.1536/ihj.23.835.
Acute myocarditis is produced in rabbits with scorpion (Buthus tamulus) (a common scorpion found in South India) venom. Acute myocarditis is confirmed by changes in the ECG taken before and after venom injection. The atrial and ventricular sarcolemmal Na+-K+ ATPase, Mg++ ATPase, and Ca++ ATPase activities are assayed in control and venom injected rabbits. Atrial and ventricular sarcolemmal ATPase activities are similar in control animals. A significant reduction in atrial Ca++ ATPase activity is seen in venom treated rabbits. Animals injected with 2 mg/Kg venom exhibited significant increases in Mg++ ATPase and Ca++ ATPase activities in the ventricular sarcolemma. However, significant reductions in Na+-K+ ATPase and Ca++ ATPase activities are observed in ventricular tissue from rabbits treated with 4 mg/Kg of venom.
用蝎子（印度南部常见的一种蝎子，即 Buthus tamulus）毒液在兔子身上诱发急性心肌炎。通过注射毒液前后所做的心电图变化来确诊急性心肌炎。对未注射毒液的对照兔子和注射毒液的兔子的心房和心室肌膜钠钾ATP酶、镁ATP酶和钙ATP酶活性进行测定。对照动物的心房和心室肌膜ATP酶活性相似。在经毒液处理的兔子中，观察到心房钙ATP酶活性显著降低。注射2毫克/千克毒液的动物，其心室肌膜中的镁ATP酶和钙ATP酶活性显著增加。然而，在用4毫克/千克毒液处理的兔子的心室组织中，观察到钠钾ATP酶和钙ATP酶活性显著降低。
