Hovendal C P, Bech K
Scand J Gastroenterol. 1982 Aug;17(5):641-5. doi: 10.3109/00365528209181072.
The prupose of this study was to elucidate the effect of the beta-adrenoceptor stimulation by isoprenaline on cholinergic-stimulated gastric acid secretion and mucosal blood flow in conscious dogs with gastric fistula. Isoprenaline, a beta 1- and beta 2-agonist, was used alone and in conjunction with selective blockade of beta 2 and beta 1 receptors. A low dose of isoprenaline had no significant effect, whereas higher doses had a significant antisecretory effect. The antisecretory effect was significantly blocked by the beta 1-adrenoceptor blocker practolol but not by H 35/25, a beta 2-adrenoceptor blocker. The dose-response curve with five doses of bethanechol with and without isoprenaline was in accordance with a non-competitive inhibition. There was no significant effect on gastric mucosal blood flow, indicating that the acid inhibition was not secondary to changes in blood flow. The inhibitory effect of isoprenaline seems to be mediated by the beta 1 receptors and with an action primarily on the 'gastrinergic receptors'.
本研究的目的是阐明在有意识的胃瘘犬中，异丙肾上腺素对β-肾上腺素能受体的刺激作用对胆碱能刺激的胃酸分泌和黏膜血流的影响。异丙肾上腺素是一种β1和β2激动剂，单独使用以及与β2和β1受体的选择性阻断剂联合使用。低剂量的异丙肾上腺素没有显著影响，而高剂量则有显著的抗分泌作用。β1肾上腺素能受体阻滞剂心得宁可显著阻断抗分泌作用，而β2肾上腺素能受体阻滞剂H 35/25则不能。在有和没有异丙肾上腺素的情况下，五剂氨甲酰甲胆碱的剂量反应曲线符合非竞争性抑制。对胃黏膜血流没有显著影响，表明酸抑制不是继发于血流变化。异丙肾上腺素的抑制作用似乎是由β1受体介导的，主要作用于“胃泌素能受体”。
