Uhlenhuth E H
J Clin Psychiatry. 1982 Dec;43(12 Pt 2):109-16.
This discussion deals with several issues of potential importance in making refined comparisons between buspirone and reference drugs as to their relative sedative and antianxiety effects (cost/benefit analyses). Factors considered that may influence the balance of sedative and antianxiety effects include drug dose, initial level of anxiety, environmental contingencies, and criteria for sedation. Additional studies of buspirone are suggested, with special reference to depression and aggression, to explore further some of the properties observed in the clinical trials presented at this symposium on "Buspirone: A Clinical Review of a New, Non-Benzodiazepine Anxiolytic."
本讨论涉及在比较丁螺环酮与参比药物的相对镇静和抗焦虑作用（成本效益分析）时可能具有潜在重要性的几个问题。所考虑的可能影响镇静和抗焦虑作用平衡的因素包括药物剂量、初始焦虑水平、环境情况以及镇静标准。建议对丁螺环酮进行更多研究，特别是关于抑郁和攻击性方面，以进一步探索在本次“丁螺环酮：一种新型非苯二氮䓬类抗焦虑药的临床综述”研讨会上所展示的临床试验中观察到的一些特性。
