Cadieux R J
Department of Psychiatry, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, USA.
Am Fam Physician. 1996 May 15;53(7):2349-53.
The azapirones are a relatively new class of psychotherapeutic drugs with both anxiolytic and antidepressant properties and a favorable benefit-to-risk ratio. They represent a significant advance in psychotherapeutic drug development. Buspirone, the only azapirone currently in clinical use, is a partial serotonin agonist with low abuse potential, no sedative effects, no cognitive or psychomotor impairment properties and no significant withdrawal symptoms. It is well-tolerated by elderly patients. Clinical indications for which buspirone is particularly appropriate are chronic anxiety and mixed anxiety/depression states. Buspirone has demonstrated some efficacy in the treatment of a broad range of other serotonin-related disorders.
氮杂螺环酮是一类相对较新的心理治疗药物，具有抗焦虑和抗抑郁特性，且效益风险比良好。它们代表了心理治疗药物开发的重大进展。丁螺环酮是目前临床使用的唯一一种氮杂螺环酮，是一种5-羟色胺部分激动剂，滥用潜力低，无镇静作用，无认知或精神运动损害特性，也无明显的戒断症状。老年患者对其耐受性良好。丁螺环酮特别适用的临床适应症是慢性焦虑和混合性焦虑/抑郁状态。丁螺环酮在治疗一系列其他与5-羟色胺相关的疾病方面已显示出一定疗效。
