Mavissakalian M
J Clin Psychiatry. 1982 Dec;43(12):487-91.
The benzodiazepines and the beta-adrenergic blockers are effective in the treatment of anxiety neurosis (generalized anxiety disorder and panic disorder) but offer little help in the treatment of agoraphobia and obsessive-compulsive disorders. The antidepressants are often effective in agoraphobia and obsessive-compulsive disorders, and the evidence suggests that their antipanic and antiobsessional effects may be independent of their antidepressant properties. There is suggestive evidence linking the antiobsessional effect to a specific neurotransmitter (serotonin) system.
苯二氮䓬类药物和β-肾上腺素能阻滞剂对焦虑症(广泛性焦虑症和惊恐障碍)的治疗有效,但对场所恐惧症和强迫症的治疗帮助不大。抗抑郁药对场所恐惧症和强迫症通常有效,且有证据表明其抗惊恐和抗强迫作用可能与其抗抑郁特性无关。有提示性证据将抗强迫作用与特定神经递质(5-羟色胺)系统联系起来。