海藻酸注射和皮质损伤对大鼠纹状体中鸟氨酸和天冬氨酸转氨酶的影响。
Effects of kainic acid injection and cortical lesion on ornithine and aspartate aminotransferases in rat striatum.
作者信息
Wong P T, McGeer E G, McGeer P L
出版信息
J Neurosci Res. 1982;8(4):643-50. doi: 10.1002/jnr.490080408.
The effects of cortical lesions and intrastriatal kainic acid injections on various striatal enzyme activities were investigated. Ornithine aminotransferase decreased concomitantly with glutamate uptake in decorticated and chronic kainic acid-treated rats. It was also decreased in acute kainic acid-lesioned striatum where glutamate uptake was unaffected. Aspartate aminotransferase, however, decreased only after acute kainic acid treatment. Results for glutamate uptake, glutamate decarboxylase, and choline acetyltransferase were in agreement with previous findings. These results suggest that ornithine may act as a precursor for glutamate in nerve terminals, although the nonspecific localization does not allow ornithine aminotransferase to be a convenient biochemical marker. The decrease in aspartate aminotransferase is thought to be due to the widespread cell degeneration after acute kainic acid. Aspartate aminotransferase activities were also found to be reduced in the frontal cortex, caudate nucleus and putamen of Huntington's disease brains.
研究了皮质损伤和纹状体内注射 kainic 酸对各种纹状体酶活性的影响。在去皮质和慢性 kainic 酸处理的大鼠中，鸟氨酸氨基转移酶与谷氨酸摄取同时降低。在急性 kainic 酸损伤的纹状体中，谷氨酸摄取未受影响，但鸟氨酸氨基转移酶也降低。然而，天冬氨酸氨基转移酶仅在急性 kainic 酸处理后降低。谷氨酸摄取、谷氨酸脱羧酶和胆碱乙酰转移酶的结果与先前的研究结果一致。这些结果表明，鸟氨酸可能在神经末梢作为谷氨酸的前体，尽管其非特异性定位使得鸟氨酸氨基转移酶不是一个方便的生化标志物。天冬氨酸氨基转移酶的降低被认为是由于急性 kainic 酸后广泛的细胞变性。在亨廷顿病大脑的额叶皮质、尾状核和壳核中也发现天冬氨酸氨基转移酶活性降低。
Zotero 插件