Aoi W, Kuramochi M, Hashiba K
Jpn Circ J. 1983 Feb;47(2):258-67. doi: 10.1253/jcj.47.258.
Role of neurohumoral factors in borderline hypertension was evaluated in comparison to those in established hypertension. Although there was no significant difference in urinary noradrenaline between the 2 groups, urinary adrenaline was significantly higher in borderline hypertension than in established hypertension. During head-up tilt and Schellong's test a significant increase of diastolic blood pressure was demonstrated in borderline hypertension, whereas a significant decrease of systolic blood pressure was observed without any significant change of diastolic pressure in established hypertension. There was no significant difference in blood pressure response to cold pressor test, plasma volume, total body potassium and plasma renin activity (PRA) between the 2 groups. Blood pressure did not change after administration of captopril in normal subjects but it decreased significantly after captopril in patients with borderline hypertension even when blood pressure became normotensive during hospitalization. Blood pressure decreased significantly after captopril in patients with established hypertension. However, no significant relationship between the pretreatment PRA and the reduction of mean blood pressure was observed in both groups. It can be concluded from the present study that borderline hypertension is intermediate between normal subjects and established hypertension and that both the renin-angiotensin system and the kinin-prostaglandin system play some role in the maintenance of blood pressure in borderline hypertension.
与确诊高血压患者相比，对神经体液因素在临界高血压中的作用进行了评估。虽然两组间尿去甲肾上腺素无显著差异，但临界高血压患者的尿肾上腺素显著高于确诊高血压患者。在头高位倾斜试验和谢隆氏试验期间，临界高血压患者的舒张压显著升高，而确诊高血压患者的收缩压显著下降，舒张压无显著变化。两组在冷加压试验的血压反应、血浆容量、全身钾和血浆肾素活性（PRA）方面无显著差异。正常受试者服用卡托普利后血压未改变，但临界高血压患者服用卡托普利后血压显著下降，即使住院期间血压已恢复正常。确诊高血压患者服用卡托普利后血压显著下降。然而，两组治疗前的PRA与平均血压降低之间均未观察到显著相关性。从本研究可以得出结论，临界高血压介于正常受试者和确诊高血压之间，肾素-血管紧张素系统和激肽-前列腺素系统在维持临界高血压患者血压方面均发挥一定作用。
