Güldner G
Pharmazie. 1982 Nov;37(11):786-90.
Experiments with male rats were performed to compare the in vitro and in vivo effects of talinolol with those of propranolol, alprenolol, practolol, proadifen (SKF 525-A) and barbital. Three in vitro model reactions (amino-phenazone N-demethylation, p-nitroanisol O-demethylation and aniline hydroxylation) as well as the hexobarbital lateral-position time served as parameters. The results obtained show that talinolol, like the other beta-receptor blockers, can inhibit polyfunctional oxidases. There were no indications of an inductive action.
对雄性大鼠进行实验，以比较他林洛尔与普萘洛尔、阿普洛尔、普拉洛尔、丙胺苯丙酮（SKF 525 - A）和巴比妥的体外和体内作用。三个体外模型反应（氨基非那宗N - 去甲基化、对硝基苯甲醚O - 去甲基化和苯胺羟化）以及己巴比妥侧位时间作为参数。所得结果表明，他林洛尔与其他β受体阻滞剂一样，能够抑制多功能氧化酶。没有诱导作用的迹象。
