Adamec R E, Stark-Adamec C
Biol Psychiatry. 1983 Feb;18(2):269-93.
The latest thinking concerning the neural mechanisms of limbic kindling is briefly reviewed. It is proposed that three types of lasting neural changes accompany the increases in epileptogenicity resulting from repetitive electrical stimulation of the limbic system in animals. Two of these, long-lasting synaptic potentiation and increased susceptibility to failure, under high drive, of neurotransmitter systems antagonistic to seizure expression, are proposed to underly the lasting interictally maintained changes in species-characteristic behavior in animals. It is proposed that similar processes may occur in some humans afflicted with complex partial epilepsy, and that these processes could explain the paradoxical relationship between seizures and psychopathology.
本文简要回顾了有关边缘系统点燃的神经机制的最新观点。研究表明，动物边缘系统经反复电刺激后，癫痫易感性增加的同时会伴随三种类型的持续性神经变化。其中两种，即长期突触增强以及在高驱动状态下对抑制癫痫发作的神经递质系统衰竭的易感性增加，被认为是动物种属特征性行为在发作间期持续变化的基础。有人提出，类似的过程可能发生在一些患有复杂部分性癫痫的人类患者身上，并且这些过程可以解释癫痫发作与精神病理学之间的矛盾关系。
