Iuzhakov S D, Morozov A V
Biull Eksp Biol Med. 1983 Apr;95(4):58-60.
It has been shown in experiments on anesthetized guinea-pigs that (+/-) and (+) propranolol produced a dose-dependent increase in the resistance of the air ways. Meanwhile oxprenolol, trimepranol and atenolol had a poor bronchoconstrictor effect, and labetalol evoked no changes in the tone of the bronchi. On an isolated trachea of the guinea-pig both forms of propranolol, as well as trimepranol and oxprenolol produced contractions, atenolol did not cause any changes in the tone of the smooth muscles, while labetalol made the smooth muscles relax. It has been also demonstrated on an isolated trachea that pretreatment with atropine, diphenhydramine, and diethylamide of lysergic acid did not lead to any noticeable changes in the bronchoconstrictive action of propranolol. At the same time verapamil and Ca2+-free Krebs solution reversed the propranolol effect.
在对麻醉豚鼠进行的实验中已表明，（±）普萘洛尔和（+）普萘洛尔可使气道阻力呈剂量依赖性增加。同时，氧烯洛尔、曲美托洛尔和阿替洛尔的支气管收缩作用较弱，而拉贝洛尔对支气管张力无影响。在豚鼠离体气管上，两种形式的普萘洛尔以及曲美托洛尔和氧烯洛尔均可引起收缩，阿替洛尔对平滑肌张力无任何影响，而拉贝洛尔可使平滑肌松弛。在离体气管上还证实，用阿托品、苯海拉明和麦角酰二乙胺预处理不会导致普萘洛尔的支气管收缩作用发生任何明显变化。同时，维拉帕米和无钙的克雷布斯溶液可逆转普萘洛尔的作用。
