Reid R E, Gariépy J, Hodges R S
FEBS Lett. 1983 Apr 5;154(1):60-4. doi: 10.1016/0014-5793(83)80875-8.
The effects of nine drugs on the CD spectra of a synthetic calcium binding analog of site III of rabbit skeletal troponin C, can generally be divided into 3 groups: (1) that consisting of haloperidol, benperidol, molindone and promethazine, had no effect on the CD spectrum or calcium sensitivity of the apopeptide; (2) that composed of structurally rigid thioxanthenes, induced CD-detectable structural change in the apopeptide but prevented Ca2+-induced structural change; (3) that consisting of chlorpromazine, trifluoperazine and fluphenazine, induced structural change in the peptide but had no effect on the Ca2+-induced structural change.
九种药物对兔骨骼肌肌钙蛋白C位点III的合成钙结合类似物的圆二色光谱的影响，通常可分为三组：（1）由氟哌啶醇、苯哌利多、吗茚酮和异丙嗪组成的一组，对载脂蛋白的圆二色光谱或钙敏感性没有影响；（2）由结构刚性的噻吨类组成的一组，在载脂蛋白中诱导出可通过圆二色检测到的结构变化，但阻止了Ca2+诱导的结构变化；（3）由氯丙嗪、三氟拉嗪和氟奋乃静组成的一组，在肽中诱导了结构变化，但对Ca2+诱导的结构变化没有影响。
