缺乏D-氨基酸氧化酶活性的小鼠突变体。
Mouse mutant deficient in D-amino acid oxidase activity.
作者信息
Konno R, Yasumura Y
出版信息
Genetics. 1983 Feb;103(2):277-85. doi: 10.1093/genetics/103.2.277.
Abstract
D-Amino acid oxidase activity in the kidney homogenates of mice of seven strains was measured to search for a mutant for this enzyme. There was a consistent sex difference in the enzyme activity in these strains: male mice showed higher levels of the enzyme activity than females. In contrast to other strains, some mice of the ddY strain did not possess enzyme activity. This trait was inheritable, and a mouse stock without enzyme activity (DAO-) was established. The allele (Dao-1c) carried by the DAO- mice was recessive and behaved as a single autosomal gene in inheritance. Heterozygous mice for this gene (Dao-1+/Dao-1c) showed nearly half the enzyme activity of the wild-type homozygotes (Dao-1+/Dao-1+), suggesting that Dao-1c is a null allele and that there is a gene dosage effect on the enzyme activity.
摘要
为寻找D-氨基酸氧化酶的突变体，对七个品系小鼠的肾脏匀浆中的该酶活性进行了测定。这些品系的酶活性存在一致的性别差异：雄性小鼠的酶活性水平高于雌性。与其他品系不同，ddY品系的一些小鼠不具有酶活性。该性状是可遗传的，并且建立了一个无酶活性的小鼠种群（DAO-）。DAO-小鼠携带的等位基因（Dao-1c）是隐性的，在遗传中表现为单个常染色体基因。该基因的杂合小鼠（Dao-1+/Dao-1c）的酶活性几乎是野生型纯合子（Dao-1+/Dao-1+）的一半，这表明Dao-1c是一个无效等位基因，并且对酶活性存在基因剂量效应。
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