Inhibition of synaptosomal neurotransmitter uptake by hallucinogens.
作者信息
Whipple M R, Reinecke M G, Gage F H
出版信息
J Neurochem. 1983 Apr;40(4):1185-8. doi: 10.1111/j.1471-4159.1983.tb08113.x.
Abstract
The effect of 13 hallucinogens on the uptake of serotonin and norepinephrine into hippocampal synaptosomes and of serotonin and dopamine into caudate synaptosomes was found to be inhibitory, except for lysergic acid diethylamide and 2-bromolysergic acid diethylamide, which were inactive. The indolealkylamines were generally more potent than the phenylethylamines. The reported inhibition of uptake of serotonin by 5-methoxy-N,N-dimethyltryptamine and lysergic acid diethylamide into whole brain synaptosomes was not reproducible at concentrations 10(2) to 10(4) times higher than those stated in the literature.
摘要
相似文献
1
Inhibition of synaptosomal neurotransmitter uptake by hallucinogens.
J Neurochem. 1983 Apr;40(4):1185-8. doi: 10.1111/j.1471-4159.1983.tb08113.x.
2
The effect of anti-synaptosomal membrane antibodies of neurotransmitter uptake.
J Neurochem. 1981 Jul;37(1):14-21. doi: 10.1111/j.1471-4159.1981.tb05285.x.
3
Neurotransmitter metabolism in rat brain synaptosomes: effect of anoxia and pH.大鼠脑突触体中的神经递质代谢：缺氧和pH值的影响。
J Neurochem. 1982 Jun;38(6):1657-67. doi: 10.1111/j.1471-4159.1982.tb06647.x.
4
Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain.3,4-亚甲基二氧甲基苯丙胺（摇头丸）及相关苯丙胺衍生物对抑制[3H]单胺摄取到大鼠脑不同区域突触体中的立体化学效应。
Biochem Pharmacol. 1987 Jul 15;36(14):2297-303. doi: 10.1016/0006-2952(87)90594-6.
5
Influence of psychotomimetics and lisuride on synaptosomal dopamine release in the nucleus accumbens of rats.
Eur J Pharmacol. 1983 Sep 30;93(3-4):213-20. doi: 10.1016/0014-2999(83)90140-1.
6
Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors?神经递质摄取机制与突触前受体之间是否存在功能联系？
J Pharmacol Exp Ther. 1984 Dec;231(3):671-7.
7
Inhibitory effect of 5-methoxy-N,N-dimethyltryptamine on the synaptosomal uptake of 5-hydroxytryptamine.5-甲氧基-N,N-二甲基色胺对5-羟色胺突触体摄取的抑制作用。
Eur J Pharmacol. 1983 Jun 3;90(2-3):293-6. doi: 10.1016/0014-2999(83)90253-4.
8
9
The effects of ibogaine on dopamine and serotonin transport in rat brain synaptosomes.伊博格碱对大鼠脑突触体中多巴胺和5-羟色胺转运的影响。
Brain Res Bull. 1999 Apr;48(6):641-7. doi: 10.1016/s0361-9230(99)00053-2.
10
Topography of synaptosomal high affinity uptake systems.突触体高亲和力摄取系统的拓扑结构。
Life Sci. 1975 Sep 1;17(5):725-33. doi: 10.1016/0024-3205(75)90527-5.
引用本文的文献
1
The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.N，N-二甲基色胺的演变：从代谢途径到脑连接性
Psychopharmacology (Berl). 2025 Apr 11. doi: 10.1007/s00213-025-06777-z.
2
Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT.N,N-二甲基色胺（DMT）在迷幻治疗学和研究中的给药和内源性 DMT 的研究。
Psychopharmacology (Berl). 2022 Jun;239(6):1749-1763. doi: 10.1007/s00213-022-06065-0. Epub 2022 Jan 22.
3
N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function.N，N-二甲基色胺（DMT），一种内源性致幻剂：确定其作用和功能的过去、现在及未来研究
Front Neurosci. 2018 Aug 6;12:536. doi: 10.3389/fnins.2018.00536. eCollection 2018.
4
Neuropharmacology of N,N-dimethyltryptamine.N,N-二甲基色胺的神经药理学
Brain Res Bull. 2016 Sep;126(Pt 1):74-88. doi: 10.1016/j.brainresbull.2016.04.016. Epub 2016 Apr 25.
5
Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.二甲色胺和其他致幻色胺在血清素摄取转运体和囊泡单胺转运体中表现出底物行为。
J Neural Transm (Vienna). 2009 Dec;116(12):1591-9. doi: 10.1007/s00702-009-0308-8. Epub 2009 Sep 12.
Zotero 插件