Labrude P, Vigneron C
J Pharm Pharmacol. 1983 Jan;35(1):23-7. doi: 10.1111/j.2042-7158.1983.tb04257.x.
Freeze-dried haemoglobin samples protected during the desiccation by sucrose, arginine aspartate, lysine aspartate, sodium-zinc EDTA and Ficoll 70 have been stored under air at 4 degrees C for 15 months. The analysis showed that sufficient concentrations of sucrose and of the amino-acid salts prevent the oxidation of haemoglobin and maintain its functional properties. Relationships between the concentrations of these compounds and the methaemoglobin levels before and after storage were calculated. They define theoretical concentration points where methaemoglobin would not be found after storage. Sucrose is slightly more effective than the amino-acid, but oppositely, EDTA and Ficoll 70 do not allow prolonged storage of freeze-dried haemoglobin.
在干燥过程中用蔗糖、天冬氨酸精氨酸、天冬氨酸赖氨酸、乙二胺四乙酸钠锌和聚蔗糖70保护的冻干血红蛋白样本，已在4摄氏度的空气中储存了15个月。分析表明，足够浓度的蔗糖和氨基酸盐可防止血红蛋白氧化并维持其功能特性。计算了这些化合物的浓度与储存前后高铁血红蛋白水平之间的关系。它们定义了储存后不会发现高铁血红蛋白的理论浓度点。蔗糖比氨基酸的效果稍好，但相反，乙二胺四乙酸和聚蔗糖70不允许冻干血红蛋白长期储存。
