阿尔茨海默病的发病机制及可能病因。

Mechanisms and possible causes of Alzheimer's disease.

作者信息

Schmidt G

出版信息

Postgrad Med. 1983 Apr;73(4):206-13. doi: 10.1080/00325481.1983.11698359.

DOI:10.1080/00325481.1983.11698359

Abstract

Alzheimer's disease has been found to be genetically transmitted. Structural changes in the disease include loss of neurons, specifically cholinergic and perhaps noradrenergic neurons. Functional connections among neurons are also lost. No cause has yet been determined, but slow viruses, autoimmune processes, and aluminum toxicity have been proposed.

摘要

已发现阿尔茨海默病具有遗传易感性。该病的结构变化包括神经元丧失，特别是胆碱能神经元，可能还有去甲肾上腺素能神经元。神经元之间的功能连接也会丧失。目前尚未确定病因，但有人提出了慢病毒、自身免疫过程和铝中毒等病因。