Rotmensch H H, Elkayam U, Frishman W
Ann Intern Med. 1983 Apr;98(4):487-97. doi: 10.7326/0003-4819-98-4-487.
Pregnancy increases the work demands on the heart by increasing blood volume and thereby cardiac output. Therefore, in pregnant patients with organic heart disease, arrhythmias may have significant hemodynamic consequences to the mother with harm to the fetus. As a result of improved medical therapy, an increasing number of women with cardiac diseases or rhythm disorders reach their reproductive years and require medication. Information on the effect of antiarrhythmic agents on the human fetus as well as the possible changes in therapeutic response during the altered state of pregnancy is limited. In principle, the approach to the treatment of arrhythmias in pregnant patients is similar to that in nonpregnant patients. Special consideration, however, must be given with regard to drug selection and dosage in order to avoid adverse effects on the mother and fetus.
怀孕会通过增加血容量从而增加心输出量，增加心脏的工作负担。因此，患有器质性心脏病的孕妇，心律失常可能对母亲产生显著的血流动力学影响，并对胎儿造成伤害。由于医疗治疗的改善，越来越多患有心脏病或心律失常的女性进入生育年龄并需要用药。关于抗心律失常药物对人类胎儿的影响以及孕期状态改变时治疗反应可能发生的变化，相关信息有限。原则上，孕妇心律失常的治疗方法与非孕妇相似。然而，在药物选择和剂量方面必须给予特别考虑，以避免对母亲和胎儿产生不良影响。
