丙吡胺对大鼠离体主动脉环的作用。
Effect of disopyramide on isolated aortic ring of the rat.
作者信息
de Moura R S, Lima J S
出版信息
Br J Pharmacol. 1983 Mar;78(3):449-51. doi: 10.1111/j.1476-5381.1983.tb08803.x.
Abstract
Disopyramide produces a contraction of the isolated aortic ring of the rat which is graded, develops slowly, and has a time course similar to the tonic phase of the noradrenaline response. This effect is not modified by alpha-adrenoceptor blockade (yohimbine) but is completely abolished by a Ca2+ antagonist (verapamil) or by removal of Ca2+ from the bathing solution. These results indicate that, in the rat aorta, disopyramide has a vasoconstrictor effect dependent on Ca2+ influx across the vascular smooth muscle membrane.
摘要
丙吡胺可使大鼠离体主动脉环产生收缩，这种收缩呈剂量依赖性，发展缓慢，其时间进程与去甲肾上腺素反应的强直期相似。α-肾上腺素能受体阻断剂（育亨宾）不会改变这种效应，但钙拮抗剂（维拉帕米）或从浴液中去除钙离子可完全消除这种效应。这些结果表明，在大鼠主动脉中，丙吡胺具有依赖于钙离子通过血管平滑肌膜内流的血管收缩作用。
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