饥饿或饥饿再投喂的日本鹌鹑（日本鹌鹑）的葡萄糖和脂质代谢变化与肝细胞精细结构的关系

Changes in glucose and lipid metabolism in starved or starved-refed Japanese quail (coturnix coturnix japonica) in relation to fine structure of liver cells.

Didier R, Remesy C, Demigne C

Comp Biochem Physiol A Comp Physiol. 1983;74(4):839-48. doi: 10.1016/0300-9629(83)90356-0.

Abstract

Metabolic response of adult quail to fasting or refeeding was studied by measuring the main blood and hepatic metabolites. Moreover, the fine structure of hepatocytes in these physiological conditions was described. 2. Starvation or refeeding did not affect glycemia in male as in female quails. 3. Fasting had no effect on plasma free fatty acids in female quails, whereas plasma triglycerides were markedly decreased. 4. In fasted quails, there was an active ketogenesis with a high 3-hydroxybutyrate/acetoacetate ratio. 5. Ultrastructural aspect of liver parenchymal cells from fasted quails revealed alterations in the quantity of glycogen, smooth endoplasmic reticulum, lysosomes and in the form of the rough endoplasmic reticulum. 6. The significance of these morphological changes was discussed in relation to an hormonal stimulation.

摘要

通过测量主要血液和肝脏代谢物，研究成年鹌鹑对禁食或重新喂食的代谢反应。此外，还描述了这些生理条件下肝细胞的精细结构。2. 饥饿或重新喂食对雄性鹌鹑和雌性鹌鹑的血糖均无影响。3. 禁食对雌性鹌鹑的血浆游离脂肪酸没有影响，而血浆甘油三酯则明显降低。4. 在禁食的鹌鹑中，存在活跃的生酮作用，3-羟基丁酸/乙酰乙酸比值较高。5. 禁食鹌鹑肝脏实质细胞的超微结构显示糖原、滑面内质网、溶酶体的数量以及粗面内质网的形态发生了改变。6. 结合激素刺激讨论了这些形态变化的意义。