豚鼠体内组胺及其代谢产物的胆汁排泄
Biliar elimination of histamine and its metabolites in guinea-pigs.
作者信息
Puerta M L, Ballestero M E
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(1):111-3. doi: 10.1016/0742-8413(83)90160-3.
PMID:6132753
Abstract
- Bile of guinea-pigs who have received [14C]-histamine contains 14C. 2. Both sexes eliminate in bile about 3.5% of the 14C administered. 3. Histamine metabolites in bile are mainly methylimidazolacetic acid and imidazolacetic acid and its riboside. 4. Acetylhistamine is present in bile. 5. Male bile contains more free histamine and methylhistamine than that of females.
摘要
- 接受过[14C] - 组胺的豚鼠胆汁中含有14C。2. 两性通过胆汁排出的14C约占给药量的3.5%。3. 胆汁中的组胺代谢产物主要是甲基咪唑乙酸、咪唑乙酸及其核苷。4. 胆汁中存在乙酰组胺。5. 雄性豚鼠胆汁中的游离组胺和甲基组胺含量高于雌性。
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