鳕鱼（ Gadus morhua）肝脏微粒体 O-脱乙基酶：它们被多氯联苯混合物Aroclor 1254诱导，但不被多氯联苯混合物Aroclor 1016诱导。
Hepatic microsomal O-de-ethylases in cod (Gadus morhua): their induction by Aroclor 1254 but not by Aroclor 1016.
作者信息
Hansen P D, Addison R F, Willis D E
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(1):173-5. doi: 10.1016/0742-8413(83)90170-6.
PMID:6132761
Abstract
- The characteristics of hepatic ethoxycoumarin and ethoxyresorufin O-de-ethylases in juvenile cod (Gadus morhua) from the North Sea are described. 2. Feeding Aroclor 1254 to juvenile cod to produce liver concentrations of approx 900 microgram X g-1 (wet wt) induced ethoxycoumarin O-de-ethylase approx 30-fold, but had no effect on ethoxyresorufin O-deethylase activity. 3. Feeding Aroclor 1016 to juvenile cod to produce liver concentrations of approx 300 micrograms X g-1 (wet wt.) did not induce ethoxycoumarin O-de-ethylase activity.
摘要
- 描述了北海幼年鳕鱼（ Gadus morhua ）肝脏中乙氧香豆素和乙氧试卤灵O -脱乙基酶的特性。2. 给幼年鳕鱼投喂多氯联苯混合物Aroclor 1254，使肝脏浓度达到约900微克/克（湿重），可诱导乙氧香豆素O -脱乙基酶活性增加约30倍，但对乙氧试卤灵O -脱乙基酶活性没有影响。3. 给幼年鳕鱼投喂多氯联苯混合物Aroclor 1016，使肝脏浓度达到约300微克/克（湿重），并未诱导乙氧香豆素O -脱乙基酶活性。
相似文献
1
Hepatic microsomal O-de-ethylases in cod (Gadus morhua): their induction by Aroclor 1254 but not by Aroclor 1016.鳕鱼（ Gadus morhua）肝脏微粒体 O-脱乙基酶：它们被多氯联苯混合物Aroclor 1254诱导，但不被多氯联苯混合物Aroclor 1016诱导。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(1):173-5. doi: 10.1016/0742-8413(83)90170-6.
2
Selective induction and inhibition of liver and lung cytochrome P-450-dependent monooxygenases by the PCBs mixture, Aroclor 1016.多氯联苯混合物Aroclor 1016对肝脏和肺细胞色素P-450依赖性单加氧酶的选择性诱导和抑制作用
Toxicology. 1985 May;35(2):83-94. doi: 10.1016/0300-483x(85)90024-1.
3
P450 induction by Aroclor 1254 and 3,3',4,4'-tetrachlorobiphenyl in cultured hepatocytes from rat, quail and man: interspecies comparison.Aroclor 1254和3,3',4,4'-四氯联苯对大鼠、鹌鹑和人类培养肝细胞中细胞色素P450的诱导作用：种间比较
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Jan;113(1):51-9. doi: 10.1016/0742-8413(95)02037-3.
4
The effect of Aroclor 1254 pretreatment on the phase I and phase II metabolism of 7-ethoxycoumarin in isolated viable rat kidney cells.
Biochem Pharmacol. 1981 Jun 1;30(11):1197-201. doi: 10.1016/0006-2952(81)90297-5.
5
Biological activity of technical Aroclor 1254 compared to Aroclor 1254 residues: swine fat residues fed to broiler cockerels.
Toxicology. 1981;21(3):203-12. doi: 10.1016/0300-483x(81)90156-6.
6
Species characteristics of the hepatic xenobiotic and steroid biotransformation systems of two teleost fish, Atlantic cod (Gadus morhua) and rainbow trout (Salmo gairdneri).两种硬骨鱼——大西洋鳕鱼（Gadus morhua）和虹鳟鱼（Salmo gairdneri）肝脏中异生素和类固醇生物转化系统的物种特征。
Toxicol Appl Pharmacol. 1987 Jul;89(3):347-60. doi: 10.1016/0041-008x(87)90154-2.
7
Effects of dietary aroclor 1254 and cyclopropene fatty acids on hepatic enzymes in rainbow trout.日粮中多氯联苯混合物1254和环丙烯脂肪酸对虹鳟鱼肝酶的影响。
Arch Environ Contam Toxicol. 1982;11(1):87-91. doi: 10.1007/BF01055191.
8
The structure-activity relationships of flavonoids as inhibitors of cytochrome P-450 enzymes in rat liver microsomes and the mutagenicity of 2-amino-3-methyl-imidazo[4,5-f]quinoline.黄酮类化合物作为大鼠肝脏微粒体中细胞色素P-450酶抑制剂的构效关系及2-氨基-3-甲基-咪唑并[4,5-f]喹啉的致突变性。
Mutagenesis. 1994 Mar;9(2):101-6. doi: 10.1093/mutage/9.2.101.
9
Induction of cytochrome P450 activities by polychlorinated biphenyls in isolated mouse hepatocytes. Influence of Ah-phenotype and iron.
Biochem Pharmacol. 1992 Aug 4;44(3):455-64. doi: 10.1016/0006-2952(92)90436-m.
10
Effects of PCBs (Aroclor 1254) on cytochrome-P450 expression and monooxygenase activities in cultured foetal rat hepatocytes.多氯联苯（Aroclor 1254）对培养的胎鼠肝细胞中细胞色素P450表达及单加氧酶活性的影响。
Toxicology. 1995 Apr 12;98(1-3):95-103. doi: 10.1016/0300-483x(94)02972-w.
Zotero 插件