西咪替丁对茶碱和环磷酸腺苷在两栖类胃黏膜中诱导的分泌及呼吸反应的抑制作用。
Inhibition by cimetidine of the secretory and respiratory responses induced by theophylline and cyclic AMP in the amphibian gastric mucosa.
作者信息
Chacín J, Cárdenas P
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(1):195-9. doi: 10.1016/0742-8413(83)90174-3.
PMID:6132765
Abstract
- The effects of cimetidine, a histamine H2-receptor antagonist, on acid secretory and respiratory responses induced by histamine, theophylline and dibutyryl cyclic AMP were investigated in the in vitro toad gastric mucosa. 2. Histamine- and theophylline-stimulated acid secretion was competitively inhibited by cimetidine. A significant but lesser degree of inhibition was observed on oxygen uptake. 3. Cimetidine significantly inhibited acid secretion and oxygen uptake stimulated by dibutyryl cyclic AMP. 4. The results may suggest that cimetidine may have an additional action beyond the point of cyclic AMP in the oxyntic cells.
摘要
- 在体外蟾蜍胃黏膜中，研究了组胺H2受体拮抗剂西咪替丁对组胺、茶碱和二丁酰环磷酸腺苷诱导的酸分泌及呼吸反应的影响。2. 西咪替丁竞争性抑制组胺和茶碱刺激的酸分泌。在氧摄取方面观察到显著但程度较小的抑制作用。3. 西咪替丁显著抑制二丁酰环磷酸腺苷刺激的酸分泌和氧摄取。4. 结果可能提示西咪替丁在壁细胞中除环磷酸腺苷作用位点外可能还有其他作用。
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