van der Kolk B A, Goldberg H L
Hosp Community Psychiatry. 1983 Apr;34(4):343-8. doi: 10.1176/ps.34.4.343.
Fifty-seven chronic schizophrenic patients were followed an average of six years after index mental hospital admission and compared on the variables of depot fluphenazine (N = 26) versus oral antipsychotic medications (N = 31), and of consistent aftercare with one therapist (N = 17) versus aftercare with multiple therapists or caregivers (N = 40). The patients who had been maintained on depot fluphenazine scored significantly better on measures of mental status than did those on oral medications, but had a significantly lower score on work performance. The group with consistent aftercare scored better on self-ratings and time without serious psychotic symptoms, but showed no difference on objective mental status when compared with the multiple-therapist aftercare group. The authors conclude that consistent aftercare and provision of medications that do not require a major commitment by the patient to remain well may make a small but significant contribution to the welfare of the chronic schizophrenic patient.
57名慢性精神分裂症患者在首次入住精神病院后平均随访了6年，并在长效氟奋乃静组（N = 26）与口服抗精神病药物组（N = 31），以及由一名治疗师持续提供后续护理组（N = 17）与由多名治疗师或护理人员提供后续护理组（N = 40）之间，就相关变量进行了比较。接受长效氟奋乃静维持治疗的患者在精神状态测量方面的得分显著高于口服药物治疗的患者，但在工作表现方面的得分显著更低。接受持续后续护理的组在自我评分和无严重精神病症状的时间方面得分更高，但与多名治疗师提供后续护理的组相比，在客观精神状态方面没有差异。作者得出结论，持续的后续护理以及提供不需要患者做出重大努力来维持健康状态的药物，可能会对慢性精神分裂症患者的福祉做出虽小但显著的贡献。
