Structure re-assignment of a metabolite of ampicillin and amoxycillin and epimerization of their penicilloic acids.
作者信息
Bird A E, Cutmore E A, Jennings K R, Marshall A C
出版信息
J Pharm Pharmacol. 1983 Mar;35(3):138-43. doi: 10.1111/j.2042-7158.1983.tb04292.x.
Abstract
Products formed in-vitro from ampicillin and amoxycillin penicilloates have been examined by high-performance liquid chromatography, ultraviolet and nuclear magnetic resonance spectroscopy and thiol group determination and were found to be the 5S epimers of the penicilloic acids. This is in contrast to a published claim that the corresponding penamaldic acids were formed by the treatment used.
摘要
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