在犬类中使用水杨酸盐增强胰岛素的直肠吸收
Enhancement of rectal absorption of insulin using salicylates in dogs.
作者信息
Nishihata T, Rytting J H, Kamada A, Higuchi T, Routh M, Caldwell L
出版信息
J Pharm Pharmacol. 1983 Mar;35(3):148-51. doi: 10.1111/j.2042-7158.1983.tb04294.x.
Abstract
Sodium salicylate and 5-methoxysalicylate both increased the rectal absorption of insulin in dogs when co-administered with insulin in various formulations. Microenema formulations containing 4% gelatin showed the highest insulin bioavailability of the formulations studied whereas microenemas (without gelatin) and suppository formulations were not as effective in enhancing the rectal absorption of insulin.
摘要
当与不同剂型的胰岛素联合给药时，水杨酸钠和5-甲氧基水杨酸盐均可增加犬类直肠对胰岛素的吸收。在所研究的剂型中，含有4%明胶的微型灌肠剂表现出最高的胰岛素生物利用度，而（不含明胶的）微型灌肠剂和栓剂剂型在增强胰岛素直肠吸收方面效果不佳。
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