Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
作者信息
van Kammen D P, Mann L S, Sternberg D E, Scheinin M, Ninan P T, Marder S R, van Kammen W B, Rieder R O, Linnoila M
出版信息
Science. 1983 May 27;220(4600):974-7. doi: 10.1126/science.6133351.
PMID:6133351
Abstract
Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.
摘要
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