多次服用阿司匹林后，使用肾脏酶作为肾毒性的早期指标。
The use of renal enzymes as early indication of renal toxicity after multiple-dose administration of aspirin.
作者信息
Meyer B H, Müller F O, Hundt H K, Grigoleit H G
出版信息
S Afr Med J. 1983 Apr 30;63(18):687-8.
Ten volunteers participated in a study comparing the effects on renal enzymes of multiple oral doses of aspirin relative to no treatment. The total urinary output was collected daily for 21 days from all subjects. The first 7 days were treatment-free. During the second 7-day period the subjects received aspirin 1500 mg 3 times daily. This was followed by another treatment-free period of 7 days. The activity of the enzymes alanine aminopeptidase and N-acetyl-beta-glucosaminidase were determined in each daily urine specimen. Statistical analysis revealed that aspirin significantly increased the output of both enzymes.
十名志愿者参与了一项研究，该研究比较了多次口服阿司匹林相对于不治疗对肾脏酶的影响。在21天内每天收集所有受试者的总尿量。前7天不进行治疗。在第二个7天期间，受试者每天服用3次1500毫克阿司匹林。随后是另一个7天的无治疗期。在每天的尿液样本中测定丙氨酸氨基肽酶和N-乙酰-β-葡萄糖苷酶的活性。统计分析表明，阿司匹林显著增加了这两种酶的排出量。
Zotero 插件