Aars H
Acta Physiol Scand. 1982 Dec;116(4):423-8. doi: 10.1111/j.1748-1716.1982.tb07161.x.
The influence of vascular beta-adrenoceptors on the tooth-supporting functions of the periodontal ligament were studied in 30 anesthetized rabbits. Propranolol and the beta 2-adrenoceptor antagonists ICI 118,551 and H 35/25 induced a marked extrusion of the incisor, probably due to reduced vasodilator tone in periodontal postcapillary blood vessels. Isoprenaline reversed the movement. beta 1- and beta 2-receptor antagonists decreased the intrusive responses to sympathetic nerve stimulation in teeth close to control position, but had no effect on responses in fully extruded teeth. Intrusive mobility, as tested by intermittent loading with 5-10 g, remained unaffected by beta-adrenoceptor blockade. The results suggest that vascular beta 2-adrenoceptors are important in the regulation of tooth position by their control of periodontal postcapillary resistance. Prejunctional beta-receptors enhancing the vasoconstrictor--and intrusive--responses to sympathetic nerve stimulation are probably a mixture of beta 1- and beta 2-receptors. It would seem that the periodontal vasculature is important for the position of the rabbit tooth but, due to rapid adaptive mechanisms of the tooth-supporting tissues, the vasculature contributes little to the resistance against load-induced intrusive movements of the tooth.
在30只麻醉兔身上研究了血管β-肾上腺素能受体对牙周膜牙齿支持功能的影响。普萘洛尔以及β2-肾上腺素能受体拮抗剂ICI 118,551和H 35/25可导致切牙明显突出，这可能是由于牙周毛细血管后血管的血管舒张张力降低所致。异丙肾上腺素可逆转这种移动。β1-和β2-受体拮抗剂降低了接近对照位置牙齿对交感神经刺激的侵入性反应，但对完全突出牙齿的反应没有影响。通过5-10克的间歇性加载测试的侵入性移动不受β-肾上腺素能受体阻断的影响。结果表明，血管β2-肾上腺素能受体通过控制牙周毛细血管后阻力在牙齿位置调节中起重要作用。增强对交感神经刺激的血管收缩和侵入性反应的突触前β-受体可能是β1-和β2-受体的混合物。看来牙周血管系统对兔牙的位置很重要，但由于牙齿支持组织的快速适应性机制，血管系统对抵抗负荷诱导的牙齿侵入性移动的贡献很小。
