Leontyeva G F, Dubrovina T Y, Taros L Y, Polyak R Y
Acta Virol. 1983 Jan;27(1):12-20.
Inoculation with influenza A virus of nonpermissive cells from the immune system of Wistar rats was followed by an abortive reproduction cycle accompanied by the synthesis of viral polypeptides on the background of substantially decreased total protein synthesis. The de novo synthesized proteins in virus-infected immune system cells were shown to represent at least two types of viral protein, namely the nucleocapsid (NP) and matrix (M) proteins. The ability of influenza virus to partial expression of the genome in immunocytes along with the reversible injury to the cell metabolism should be taken into account in evaluating the possible mechanisms of action of influenza A virus on the functional activity of cells of the immune system.
用甲型流感病毒接种来自Wistar大鼠免疫系统的非允许细胞后，会出现一个流产性繁殖周期，同时在总蛋白合成大幅减少的背景下合成病毒多肽。病毒感染的免疫系统细胞中重新合成的蛋白质显示至少代表两种类型的病毒蛋白，即核衣壳（NP）蛋白和基质（M）蛋白。在评估甲型流感病毒对免疫系统细胞功能活性的可能作用机制时，应考虑流感病毒在免疫细胞中部分表达基因组的能力以及对细胞代谢的可逆性损伤。
