Heath A, Gabrielsson M, Redgårdh C G
Br J Clin Pharmacol. 1983 Apr;15(4):490-2. doi: 10.1111/j.1365-2125.1983.tb01535.x.
The adsorption of beta-adrenoceptor blockers and the partial beta-adrenoceptor agonist prenalterol was studied in an in vitro haemoperfusion (HP) model. Metoprolol, alprenolol, propranolol and prenalterol adsorb well from the blood to the resin with extraction ratios nearing 1.0. Extraction ratio for practolol was 0.68 and for atenolol 0.49. Protein binding has little effect on the degree of adsorption, which is more dependent on water solubility.
在体外血液灌流(HP)模型中研究了β-肾上腺素能受体阻滞剂和部分β-肾上腺素能受体激动剂普瑞特罗的吸附情况。美托洛尔、阿普洛尔、普萘洛尔和普瑞特罗从血液到树脂的吸附良好,萃取率接近1.0。醋丁洛尔的萃取率为0.68,阿替洛尔为0.49。蛋白质结合对吸附程度影响不大,吸附程度更取决于水溶性。