Shimatsu A, Kato Y, Tanaka I, Nakai Y, Fukunaga M, Imura H
Clin Endocrinol (Oxf). 1983 Feb;18(2):119-25. doi: 10.1111/j.1365-2265.1983.tb03193.x.
In a case study of medullary thyroid carcinoma (MTC) associated with Cushing's syndrome, elevated levels of urinary 17-hydroxycorticosteroids, plasma ACTH, cortisol, calcitonin (CT) and somatostatin (GHRIH) were documented. Lysine vasopressin administration further increased the levels of plasma ACTH, cortisol and CT, whereas the administration of calcium and pentagastrin increased only the level of plasma CT. Immunoreactive ACTH, CT and GHRIH were highly concentrated in the tumour tissues. Basal plasma ACTH levels were more progressively increased than plasma CT during the postoperative course when the patient was treated with o,p'-DDD, since the tumour was not completely resected. These findings suggest that the secretion of ACTH and CT from MTC were regulated in a different manner.
在一项与库欣综合征相关的甲状腺髓样癌（MTC）病例研究中，记录到尿17-羟皮质类固醇、血浆促肾上腺皮质激素（ACTH）、皮质醇、降钙素（CT）和生长抑素（GHRIH）水平升高。给予赖氨酸加压素进一步提高了血浆ACTH、皮质醇和CT水平，而给予钙和五肽胃泌素仅提高了血浆CT水平。免疫反应性ACTH、CT和GHRIH在肿瘤组织中高度浓缩。由于肿瘤未完全切除，术后患者接受邻对滴滴滴（o,p'-DDD）治疗时，基础血浆ACTH水平比血浆CT水平升高得更明显。这些发现表明，MTC分泌ACTH和CT的调节方式不同。
