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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Thabrew M I, Emerole G O

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(2):473-6. doi: 10.1016/0742-8413(83)90134-2.

The effects of the herbicide 1.1.1. trifluoro-N-(2-methyl-4-phenyl sulfonyl phenyl) methane sulfonamide on the drug metabolising enzyme activities in livers of rat, mouse and guinea pig have been compared. 2. In all three animal models, the herbicide increased the activities of both aniline hydroxylase and p-aminopyrine demethylase. The greatest inductive effect was seen in the rat, while the least effect was evident in the guinea pig. 3. In mouse and guinea pig, 1.1.1. trifluoro-N-(2-methyl-4-phenyl sulfonyl phenyl) methane sulfonamide had no effect on the soluble or microsomal epoxide hydratases or the glutathione S-transferases. In the rat, however, the herbicide significantly decreased the microsomal epoxide hydratase activity, as well as the soluble and microsomal glutathione S-transferase activities. 4. These results are discussed in relation to factors responsible for species differences in the response to foreign compounds.

已比较了除草剂1.1.1. 三氟 - N - (2 - 甲基 - 4 - 苯基磺酰基苯基)甲磺酰胺对大鼠、小鼠和豚鼠肝脏中药物代谢酶活性的影响。2. 在所有三种动物模型中，该除草剂均增加了苯胺羟化酶和对氨基苯丙胺脱甲基酶的活性。大鼠的诱导作用最强，而豚鼠的作用最不明显。3. 在小鼠和豚鼠中，1.1.1. 三氟 - N - (2 - 甲基 - 4 - 苯基磺酰基苯基)甲磺酰胺对可溶性或微粒体环氧化物水合酶或谷胱甘肽S - 转移酶没有影响。然而，在大鼠中，该除草剂显著降低了微粒体环氧化物水合酶活性以及可溶性和微粒体谷胱甘肽S - 转移酶活性。4. 结合对外源化合物反应中物种差异的相关因素对这些结果进行了讨论。

Thabrew M I, Emerole G O

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(2):473-6. doi: 10.1016/0742-8413(83)90134-2.

The effects of the herbicide 1.1.1. trifluoro-N-(2-methyl-4-phenyl sulfonyl phenyl) methane sulfonamide on the drug metabolising enzyme activities in livers of rat, mouse and guinea pig have been compared. 2. In all three animal models, the herbicide increased the activities of both aniline hydroxylase and p-aminopyrine demethylase. The greatest inductive effect was seen in the rat, while the least effect was evident in the guinea pig. 3. In mouse and guinea pig, 1.1.1. trifluoro-N-(2-methyl-4-phenyl sulfonyl phenyl) methane sulfonamide had no effect on the soluble or microsomal epoxide hydratases or the glutathione S-transferases. In the rat, however, the herbicide significantly decreased the microsomal epoxide hydratase activity, as well as the soluble and microsomal glutathione S-transferase activities. 4. These results are discussed in relation to factors responsible for species differences in the response to foreign compounds.

已比较了除草剂1.1.1. 三氟 - N - (2 - 甲基 - 4 - 苯基磺酰基苯基)甲磺酰胺对大鼠、小鼠和豚鼠肝脏中药物代谢酶活性的影响。2. 在所有三种动物模型中，该除草剂均增加了苯胺羟化酶和对氨基苯丙胺脱甲基酶的活性。大鼠的诱导作用最强，而豚鼠的作用最不明显。3. 在小鼠和豚鼠中，1.1.1. 三氟 - N - (2 - 甲基 - 4 - 苯基磺酰基苯基)甲磺酰胺对可溶性或微粒体环氧化物水合酶或谷胱甘肽S - 转移酶没有影响。然而，在大鼠中，该除草剂显著降低了微粒体环氧化物水合酶活性以及可溶性和微粒体谷胱甘肽S - 转移酶活性。4. 结合对外源化合物反应中物种差异的相关因素对这些结果进行了讨论。