谷胱甘肽依赖的N,N'-双(2-氯乙基)N-亚硝基脲（BCNU）脱亚硝基作用：小鼠肝脏胞质溶胶在体外催化亚硝酸盐释放 - Suppr

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Glutathione-dependent denitrosation of N,N'-bis(2-chloroethyl)N-nitrosourea (BCNU): nitrite release catalyzed by mouse liver cytosol in vitro.

作者信息

Talcott R E, Levin V A

出版信息

Drug Metab Dispos. 1983 Mar-Apr;11(2):175-6.

PMID:6133726

Abstract

摘要

相似文献

Glutathione-dependent denitrosation of N,N'-bis(2-chloroethyl)N-nitrosourea (BCNU): nitrite release catalyzed by mouse liver cytosol in vitro.谷胱甘肽依赖的N,N'-双(2-氯乙基)N-亚硝基脲（BCNU）脱亚硝基作用：小鼠肝脏胞质溶胶在体外催化亚硝酸盐释放

Drug Metab Dispos. 1983 Mar-Apr;11(2):175-6.

Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases.微粒体谷胱甘肽S-转移酶和细胞色素P450单加氧酶催化抗癌药物1,3-双(2-氯乙基)-1-亚硝基脲的脱亚硝化反应。

Arch Biochem Biophys. 1993 Dec;307(2):369-78. doi: 10.1006/abbi.1993.1602.

Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells.1,3-双（2-氯乙基）-1-亚硝基脲经μ类谷胱甘肽转移酶的脱亚硝化作用及其在大鼠脑肿瘤细胞耐药性中的作用

Cancer Res. 1989 May 15;49(10):2621-5.

Measurement and characterization of the denitrosation of tauromustine and related nitrosoureas by glutathione transferases in liver cytosol from various species.谷胱甘肽转移酶对不同物种肝脏胞质溶胶中牛磺莫司汀及相关亚硝基脲脱亚硝基作用的测定与表征

Carcinogenesis. 1993 Jun;14(6):1143-7. doi: 10.1093/carcin/14.6.1143.

Microsomal metabolism of nitrosoureas.亚硝基脲的微粒体代谢

Cancer Res. 1975 Feb;35(2):296-301.

Metabolism of 1,3-bis(2-chloroethyl)-1-nitrosourea by rat hepatic microsomes.大鼠肝微粒体对1,3-双（2-氯乙基）-1-亚硝基脲的代谢

J Med Chem. 1981 Jun;24(6):761-3. doi: 10.1021/jm00138a025.

Reduction of glutathione levels in livers of mice treated with N,N'-bis (2-chloroethyl)-N-nitrosourea.用N，N'-双（2-氯乙基）-N-亚硝基脲处理的小鼠肝脏中谷胱甘肽水平的降低。

Cancer Chemother Pharmacol. 1979;2(3):221-3. doi: 10.1007/BF00258299.

Preferential effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on pulmonary glutathione reductase and glutathione/glutathione disulfide ratios: possible implications for lung toxicity.

J Pharmacol Exp Ther. 1984 Jun;229(3):658-63.

The effects of BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) and CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) on glutathione reductase and other enzymes in mouse tissue.

Res Commun Chem Pathol Pharmacol. 1983 Jun;40(3):355-66.

Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.抗肿瘤前药氯乙亚硝脲和卡莫司汀产生的异氰酸酯对细胞谷胱甘肽还原酶活性的差异抑制作用。

Biochem Pharmacol. 2005 May 15;69(10):1463-72. doi: 10.1016/j.bcp.2005.02.016.

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Cyclophosphamide, cisplatin, and carmustine: pharmacokinetics of carmustine following multiple alkylating-agent interactions.

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