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[放射性核素研究β-肾上腺素能阻滞剂对强心苷强心作用的影响]

[Radionuclide study of the influence of beta-adrenoblockaders on the cardiotonic effect of cardiac glycosides].

作者信息

Gendenshteĭn E I, Vladimirov Iu P, Koledinov V I, Zaĭtsev V M

出版信息

Farmakol Toksikol. 1983 Mar-Apr;46(2):68-72.

PMID:6133778
Abstract

Radiocardiography was used in 234 patients to explore the effect of corglycon, a glycoside drug obtained from Convallaria L., cardiac glycoside (CG) digoxin, beta-adrenoblockers (BAB) anapriline and trasicor, and combinations of CG and BAB on the minute and stroke volumes of the circulation and heart rate. It has been shown that administration of CG coupled with BAB increasing the tolerance to the cardiotoxic effect of CG does not entail a reduction of their beneficial inotropic action.

摘要

对234例患者进行了放射心动描记术,以探讨从铃兰中提取的糖苷类药物毒毛旋花子苷、强心苷(CG)地高辛、β-肾上腺素能阻滞剂(BAB)心得安和氨酰心安,以及CG与BAB联合用药对循环系统每分输出量、每搏输出量和心率的影响。结果表明,CG与BAB联合用药可提高对CG心脏毒性作用的耐受性,且不会降低其有益的正性肌力作用。

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