甲氧氟烷性肝炎：两例产科镇痛后病例

Methoxyflurane hepatitis: two cases following obstetric analgesia.

作者信息

Delia J E, Maxson W S, Breen J L

出版信息

Int J Gynaecol Obstet. 1983 Feb;21(1):89-93. doi: 10.1016/0020-7292(83)90076-0.

Abstract

Methoxyflurane is utilized in obstetrics for analgesia during labor. It has been recognized as an unpredictable hepatotoxin. Although hepatitis has been seen after its use in anesthesia, only one case of hepatitis has been reported after its use for analgesia in labor. Two more cases of hepatitis following methoxyflurane analgesia are reported. Direct toxic effects of its metabolites and host idiosyncrasy may underlie the hepatic injury from methoxyflurane.

摘要

甲氧氟烷用于产科分娩镇痛。它已被公认为一种不可预测的肝毒素。尽管在麻醉中使用后曾出现过肝炎，但用于分娩镇痛后仅报告过1例肝炎病例。本文报告另外2例甲氧氟烷镇痛后出现肝炎的病例。其代谢产物的直接毒性作用和宿主特异性可能是甲氧氟烷所致肝损伤的基础。