Cohen I S, Widrich W, Duchin K L, Wharton T P, Fluri-Lundeen J, Hargus S M
J Clin Pharmacol. 1983 Feb-Mar;23(2-3):93-9. doi: 10.1002/j.1552-4604.1983.tb02710.x.
The acute effects of intravenous nadolol (0.01 and 0.02 mg/kg) on cardiac electrophysiologic parameters were assessed with His bundle recording and programmed atrial stimulation. The higher dose of nadolol reduced resting heart rate (71 vs. 65 beats/min, P less than 0.02), and the degree of slowing was related to the initial heart rate (r = -0.68, P less than 0.05). Atrioventricular conduction time as defined by the paced A-H interval, rose by 12 msec (P less than 0.001) after nadolol (0.02 mg/kg) administration. Atrial refractoriness increased (by 10 msec, P less than 0.02) only at the higher dose level with nadolol. At both dose levels, atrioventricular nodal effective and functional refractory periods were increased (P less than 0.02) by a mean of 45 and 21 msec, respectively, suggesting greater sensitivity of atrioventricular nodal refractoriness to beta-adrenergic blockade. Nadolol's effects were generally similar to those of previously reported studies with other beta-adrenergic blockers. These data suggest that nadolol slows conduction through the atrioventricular node and increases atrial and atrioventricular nodal refractoriness.
通过希氏束记录和程控心房刺激评估静脉注射纳多洛尔（0.01和0.02mg/kg）对心脏电生理参数的急性影响。较高剂量的纳多洛尔降低了静息心率（71次/分钟对65次/分钟，P<0.02），且减慢程度与初始心率相关（r=-0.68，P<0.05）。在给予纳多洛尔（0.02mg/kg）后，由起搏A-H间期定义的房室传导时间增加了12毫秒（P<0.001）。仅在较高剂量水平的纳多洛尔作用下，心房不应期增加（增加10毫秒，P<0.02）。在两个剂量水平下，房室结有效不应期和功能不应期分别平均增加了45毫秒和21毫秒（P<0.02），提示房室结不应期对β-肾上腺素能阻滞剂更为敏感。纳多洛尔的作用通常与先前报道的其他β-肾上腺素能阻滞剂的研究结果相似。这些数据表明，纳多洛尔减慢通过房室结的传导，并增加心房和房室结的不应期。
