Borbély A A, Mattmann P, Loepfe M, Fellmann I, Gerne M, Strauch I, Lehmann D
Eur J Pharmacol. 1983 Apr 22;89(1-2):157-61. doi: 10.1016/0014-2999(83)90622-2.
All-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the frequency range of sleep spindles. In the subsequent drug-free night, the latter changes were no longer present after triazolam, whereas the reduction of slow wave activity persisted after all compounds.
