• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

β-肾上腺素能激动剂对大鼠肺中磷脂酶A2的体内抑制作用。

In vivo inhibition of phospholipase A2 in rat lung by an beta-adrenergic agonist.

作者信息

Wichert P V, Meyer W

出版信息

Agents Actions. 1983 Apr;13(2-3):233-4. doi: 10.1007/BF01967339.

DOI:10.1007/BF01967339
PMID:6135325
Abstract

Phospholipase A2 is the key enzyme for the release of arachidonic acid derived mediators via cycloxygenase or lipoxygenase pathways in inflammation and immunological processes. Activity of microsomal phospholipase A2 in rat lung can be inhibited by in vivo application of the beta-adrenergic drug fenoterol both in control and diseased animals.

摘要

磷脂酶A2是在炎症和免疫过程中通过环氧化酶或脂氧合酶途径释放花生四烯酸衍生介质的关键酶。在对照动物和患病动物中，体内应用β-肾上腺素能药物非诺特罗均可抑制大鼠肺微粒体磷脂酶A2的活性。

相似文献

1
In vivo inhibition of phospholipase A2 in rat lung by an beta-adrenergic agonist.β-肾上腺素能激动剂对大鼠肺中磷脂酶A2的体内抑制作用。
Agents Actions. 1983 Apr;13(2-3):233-4. doi: 10.1007/BF01967339.
2
Inhibition of phospholipase A2 activity by Fluosol, an artificial blood substitute.
Prostaglandins. 1982 Jun;23(6):919-27. doi: 10.1016/0090-6980(82)90134-4.
3
Studies on the arachidonic acid cascade--I. Inhibition of phospholipase A2 in vitro and in vivo by several novel series of inhibitor compounds.花生四烯酸级联反应的研究——I. 几种新型抑制剂化合物在体外和体内对磷脂酶A2的抑制作用
Biochem Pharmacol. 1981 Jun 1;30(11):1315-24. doi: 10.1016/0006-2952(81)90315-4.
4
Effects of hypolaetin-8-glucoside and related flavonoids on soybean lipoxygenase and snake venom phospholipase A2.
Arch Int Pharmacodyn Ther. 1985 Nov;278(1):4-12.
5
Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.在FRTL5甲状腺细胞中，磷脂酶A2和磷脂酶C在α1-肾上腺素能刺激下由不同的GTP结合蛋白激活。
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7201-5. doi: 10.1073/pnas.83.19.7201.
6
Effect of various blockers of arachidonic acid metabolism on release of beta-endorphin- and adrenocorticotropin-like immunoreactivity induced by phospholipase A2 from rat adenohypophysis in vitro.体外培养条件下，多种花生四烯酸代谢阻滞剂对大鼠腺垂体中磷脂酶A2诱导的β-内啡肽和促肾上腺皮质激素样免疫反应性释放的影响。
Neuroendocrinology. 1986;43(1):44-8. doi: 10.1159/000124507.
7
Inhibition by ethanol and mepacrine of phospholipase-dependent prostaglandin release from the isolated perfused rat lung.
Eur J Pharmacol. 1986 Jan 21;120(2):145-50. doi: 10.1016/0014-2999(86)90534-0.
8
Enhancement of insulin release due to inhibition of phospholipase A2 activity.
Horm Metab Res. 1983 May;15(5):255-6. doi: 10.1055/s-2007-1018686.
9
Calmodulin-independent inhibition of platelet phospholipase A2 by calmodulin antagonists.钙调蛋白拮抗剂对血小板磷脂酶A2的非钙调蛋白依赖性抑制作用。
Arch Biochem Biophys. 1986 May 1;246(2):699-709. doi: 10.1016/0003-9861(86)90326-7.
10
Vitamin E inhibits platelet phospholipase A2.维生素E抑制血小板磷脂酶A2。
Biochim Biophys Acta. 1986 May 21;876(3):639-45. doi: 10.1016/0005-2760(86)90053-6.

引用本文的文献

1
Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones.速激肽和辣椒素对豚鼠支气管副交感神经节神经元的电生理效应。
J Physiol. 1993 Oct;470:665-79. doi: 10.1113/jphysiol.1993.sp019881.
2
Prostaglandins and the lung.前列腺素与肺
Lung. 1986;164(2):65-77. doi: 10.1007/BF02713630.

本文引用的文献

1
Studies on the arachidonic acid cascade--I. Inhibition of phospholipase A2 in vitro and in vivo by several novel series of inhibitor compounds.花生四烯酸级联反应的研究——I. 几种新型抑制剂化合物在体外和体内对磷脂酶A2的抑制作用
Biochem Pharmacol. 1981 Jun 1;30(11):1315-24. doi: 10.1016/0006-2952(81)90315-4.
2
Pulmonary injury and prostaglandin production during endotoxemia in conscious sheep.清醒绵羊内毒素血症期间的肺损伤与前列腺素生成
Am J Physiol. 1981 Mar;240(3):H348-53. doi: 10.1152/ajpheart.1981.240.3.H348.
3
Influence of septic shock upon phosphatidylcholine remodeling mechanism in rat lung.
脓毒性休克对大鼠肺组织中磷脂酰胆碱重塑机制的影响。
Biochim Biophys Acta. 1981 Jun 23;664(3):487-97. doi: 10.1016/0005-2760(81)90127-2.
4
Impaired pulmonary surfactant synthesis in starvation and severe nonthoracic sepsis.饥饿和严重非胸部脓毒症时肺表面活性物质合成受损。
Am J Surg. 1972 Apr;123(4):461-7. doi: 10.1016/0002-9610(72)90200-0.
5
Altered metabolism of phospholipids in the lung of rats with peritonitis.腹膜炎大鼠肺组织中磷脂代谢的改变。
Res Exp Med (Berl). 1978 Jun 12;172(3):223-9. doi: 10.1007/BF01855832.
6
Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation.抗炎类固醇诱导一种磷脂酶A2抑制剂的生物合成，该抑制剂可阻止前列腺素的生成。
Nature. 1979 Mar 29;278(5703):456-9. doi: 10.1038/278456a0.
7
Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation.从大鼠分离出的肺泡II型细胞。对β-肾上腺素能刺激的反应中磷脂酰胆碱的释放。
J Clin Invest. 1979 Mar;63(3):378-87. doi: 10.1172/JCI109313.
8
Control of lung surfactant by ventilation, adrenergic mediators, and prostaglandins in the rabbit.家兔中通气、肾上腺素能介质和前列腺素对肺表面活性物质的调控
Am Rev Respir Dis. 1978 May;117(5):879-91. doi: 10.1164/arrd.1978.117.5.879.