Thomson A B, Hotke C A, O'Brien B D, Weinstein W M
Comp Biochem Physiol A Comp Physiol. 1983;75(2):221-32. doi: 10.1016/0300-9629(83)90074-9.
The uptake (Jd) of fatty acids (FA), fatty alcohols (Alc) and cholesterol (C) into the jejunum of rats (R, Rattus norvegicus), rabbits (RAB, Oryctolagus cuniculus), guinea pigs (GB, Cavia porcellus), and hamsters (H, Mesocricetus auratus) was assessed in vitro. Using jejunal discs the Jd of Alc was H greater than R = GP greater than RAB, the Jd of FA was H-RAB greater than R greater than GP, but the Jd of C was R greater than H greater than RAB greater than GP. The Jd of FA was quantitatively and qualitatively different when using jejunal biopsies; in man the Jd of FA into biopsies was greater than in the other animal species, but there was no difference in Jd of FA into normal human jejunal biopsies and those showing severe abnormalities in villus architecture. There are marked species differences in the passive permeability properties of the jejunum and in the effective resistance of the overlying unstirred water layer, but these differences do not explain the species variations in the uptake of cholesterol.
体外评估了大鼠（R，褐家鼠）、兔（RAB，穴兔）、豚鼠（GB，豚鼠）和仓鼠（H，金黄地鼠）空肠对脂肪酸（FA）、脂肪醇（Alc）和胆固醇（C）的摄取（Jd）。使用空肠切片时，Alc的Jd为H大于R = GP大于RAB，FA的Jd为H - RAB大于R大于GP，但C的Jd为R大于H大于RAB大于GP。使用空肠活检时，FA的Jd在数量和质量上有所不同；在人类中，FA进入活检组织的Jd大于其他动物物种，但FA进入正常人类空肠活检组织和绒毛结构严重异常的活检组织的Jd没有差异。空肠的被动通透性特性和覆盖的未搅拌水层的有效阻力存在明显的物种差异，但这些差异并不能解释胆固醇摄取的物种差异。
